Pub. Date : 2016 Jan
PMID : 26796799
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To investigate the changes of ID1 expression in tumor cells treated with etoposide, cisplatin and ultraviolet (UV) irradiation, and explore the effect of ID1 on chemotherapeutic drug- and UV-induced apoptosis. | Etoposide | inhibitor of DNA binding 1, HLH protein | Homo sapiens |
| 2 | METHODS: In the present study, upon onset of apoptosis induced by various kinds of inducers such as etoposide, cisplatin and UV irradiation, the expression level of ID1 was detected by Western blot and real-time PCR. | Etoposide | inhibitor of DNA binding 1, HLH protein | Homo sapiens |
| 3 | RESULTS: ID1 expression presented a profound down-regulation in the HCT116 cells treated with etoposide, cisplatin and UV irradiation(P<0.05 for all). | Etoposide | inhibitor of DNA binding 1, HLH protein | Homo sapiens |
| 4 | Upon etoposide treatment, ID1 expression level was decreased via induction of mRNA instability, but not the protein degradation changes. | Etoposide | inhibitor of DNA binding 1, HLH protein | Homo sapiens |
| 5 | Additionally, ectopic expression of ID1 in the HCT116 cells alleviated etoposide-, cisplatin- and UV-induced apoptosis. | Etoposide | inhibitor of DNA binding 1, HLH protein | Homo sapiens |
| 6 | CONCLUSIONS: These observations indicate that the treatment with etoposide reduces the amount of ID1 by induction of mRNA instability, and exogenously introduced ID1 protects cells against etoposide-, cisplatin- and UV irradiation-induced apoptosis. | Etoposide | inhibitor of DNA binding 1, HLH protein | Homo sapiens |
| 7 | CONCLUSIONS: These observations indicate that the treatment with etoposide reduces the amount of ID1 by induction of mRNA instability, and exogenously introduced ID1 protects cells against etoposide-, cisplatin- and UV irradiation-induced apoptosis. | Etoposide | inhibitor of DNA binding 1, HLH protein | Homo sapiens |