Pub. Date : 2016 Feb 5
PMID : 26792731
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | cAMP signaling increases histone deacetylase 8 expression by inhibiting JNK-dependent degradation via autophagy and the proteasome system in H1299 lung cancer cells. | Cyclic AMP | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | cAMP signaling inhibited JNK activation, which decreased the phosphorylation of Bcl-2, thereby reducing autophagy, and the phosphorylation of Itch, thereby reducing ubiquitination. | Cyclic AMP | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | These results suggest that the HDAC8 protein is degraded via autophagy and the ubiquitin-proteasome system and that cAMP signaling increases HDAC8 protein levels by reducing JNK-mediated autophagy and ubiquitin-proteasome-dependent degradation of the HDAC8 protein in H1299 lung cancer cells. | Cyclic AMP | mitogen-activated protein kinase 8 | Homo sapiens |