Title : In vivo regulation of human CrkII by cyclophilin A and FK506-binding protein.

Pub. Date : 2016 Feb 5

PMID : 26792730






2 Functional Relationships(s)
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1 Utilizing human Jurkat T cells, we demonstrate that CrkII-SH3N binding of C3G is inhibited by cyclosporin A (CsA) plus FK506 that inhibit the cyclophilin A (CypA) and FK506 binding protein (FKBP) peptidyl-prolyl cis-trans isomerases (PPIases; also termed immunophilins), respectively. Tacrolimus peptidylprolyl isomerase A Homo sapiens
2 Utilizing human Jurkat T cells, we demonstrate that CrkII-SH3N binding of C3G is inhibited by cyclosporin A (CsA) plus FK506 that inhibit the cyclophilin A (CypA) and FK506 binding protein (FKBP) peptidyl-prolyl cis-trans isomerases (PPIases; also termed immunophilins), respectively. Tacrolimus peptidylprolyl isomerase A Homo sapiens