Title : Pathophysiological Role of Peroxynitrite Induced DNA Damage in Human Diseases: A Special Focus on Poly(ADP-ribose) Polymerase (PARP).

Pub. Date : 2015 Oct

PMID : 26788021






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 A DNA nick sensing enzyme, poly(ADP-ribose) polymerase-1 (PARP-1) becomes activated upon detecting DNA breakage and it cleaves NAD(+) into nicotinamide and ADP-ribose and polymerizes the latter on nuclear acceptor proteins. Niacinamide poly(ADP-ribose) polymerase 1 Homo sapiens
2 A DNA nick sensing enzyme, poly(ADP-ribose) polymerase-1 (PARP-1) becomes activated upon detecting DNA breakage and it cleaves NAD(+) into nicotinamide and ADP-ribose and polymerizes the latter on nuclear acceptor proteins. Niacinamide poly(ADP-ribose) polymerase 1 Homo sapiens