Title : Commentary to Gorelenkova Miller and Mieyal (2015): sulfhydryl-mediated redox signaling in inflammation: role in neurodegenerative diseases.

Pub. Date : 2016 Apr

PMID : 26780347






2 Functional Relationships(s)
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1 The oxidative stresses also modulate kinase activity of RET-PTC1 with cysteine 365 (C365) replaced by alanine with promotion of dimer formation, but not with cysteine 376 (C376) replaced by alanine. Cysteine ret proto-oncogene Homo sapiens
2 Since C376 of Ret-PTC-1 or its equivalent is most highly conserved and crucial for activity in PTKs, the cysteine could be one of major targets for oxidative stresses. Cysteine ret proto-oncogene Homo sapiens