Pub. Date : 2016 Jul
PMID : 26779636
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lycopene acts through inhibition of IkappaB kinase to suppress NF-kappaB signaling in human prostate and breast cancer cells. | Lycopene | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | We studied the effect of the potent dietary antioxidant lycopene on multiple points along the nuclear factor kappa B (NF-kappaB) signaling pathway in prostate and breast cancer cells. | Lycopene | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | We studied the effect of the potent dietary antioxidant lycopene on multiple points along the nuclear factor kappa B (NF-kappaB) signaling pathway in prostate and breast cancer cells. | Lycopene | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Furthermore, the same degree of inhibition by lycopene was observed for NF-kappaB transcriptional activity, as determined by reporter gene assay. | Lycopene | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | Concomitant with this, immunofluorescence staining of lycopene-treated cells showed a significant suppression (>=25 %) of TNF-induced NF-kappaB p65 subunit nuclear translocation. | Lycopene | nuclear factor kappa B subunit 1 | Homo sapiens |
| 6 | Further probing of lycopene"s effects on upstream elements of the NF-kappaB pathway showed a 25 % inhibition of both activity of recombinant IkappaB kinase beta (IKKbeta) kinase in a cell-free in vitro assay, as well as activity of IKKbeta immunoprecipitated from MDA-MB-231 cells treated with lycopene. | Lycopene | nuclear factor kappa B subunit 1 | Homo sapiens |
| 7 | Further probing of lycopene"s effects on upstream elements of the NF-kappaB pathway showed a 25 % inhibition of both activity of recombinant IkappaB kinase beta (IKKbeta) kinase in a cell-free in vitro assay, as well as activity of IKKbeta immunoprecipitated from MDA-MB-231 cells treated with lycopene. | Lycopene | nuclear factor kappa B subunit 1 | Homo sapiens |
| 8 | In conclusion, the anticancer properties of lycopene may occur through inhibition of the NF-kappaB signaling pathway, beginning at the early stage of cytoplasmic IKK kinase activity, which then leads to reduced NF-kappaB-responsive gene regulation. | Lycopene | nuclear factor kappa B subunit 1 | Homo sapiens |
| 9 | In conclusion, the anticancer properties of lycopene may occur through inhibition of the NF-kappaB signaling pathway, beginning at the early stage of cytoplasmic IKK kinase activity, which then leads to reduced NF-kappaB-responsive gene regulation. | Lycopene | nuclear factor kappa B subunit 1 | Homo sapiens |