Pub. Date : 2016 Apr
PMID : 26776764
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin reverses benzidine-induced cell proliferation by suppressing ERK1/2 pathway in human bladder cancer T24 cells. | Curcumin | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | Treatment with ERK1/2 inhibitor U0126 or curcumin effectively abrogated benzidine-triggered cell proliferation and ERK1/2/AP-1 activation. | Curcumin | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | These results suggested for the first time that curcumin in low concentrations played a protective role in benzidine-induced ERK1/2/AP-1 activation and proliferation of bladder cancer cells, therefore providing new insights into the pathogenesis and chemoprevention of benzidine-associated bladder cancer. | Curcumin | mitogen-activated protein kinase 3 | Homo sapiens |