Title : The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4.

Pub. Date : 2016 May

PMID : 26774838






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We directly demonstrate that the binding of two steroid molecules, which can assume multiple possible configurations inside the substrate binding pocket of monomeric CYP3A4, can lead to active site structural changes that affect functional properties. Steroids cytochrome P450 family 3 subfamily A member 4 Homo sapiens