Title : The effect of GH treatment on serum FGF23 and Klotho in GH-deficient children.

Pub. Date : 2016 Apr

PMID : 26764419






3 Functional Relationships(s)
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1 The phosphaturic fibroblast growth factor 23 (FGF23)/Klotho axis is a major regulator of phosphate homeostasis; therefore, an intact FGF23/Klotho axis is important for normal linear growth. Phosphates klotho Homo sapiens
2 AIM: The main objective of this study was to investigate the possible interactions of FGF23 and its co-receptor Klotho, with growth hormone (GH)/IGF1 axis in the regulation of phosphate metabolism in GH-deficient children under GH treatment. Phosphates klotho Homo sapiens
3 CONCLUSION: The increase in serum phosphate, which we found in GH-deficient children under GH treatment, is not associated with suppression but rather than with upregulation of the phosphaturic FGF23/Klotho axis. Phosphates klotho Homo sapiens