Pub. Date : 2016 Dec
PMID : 26756900
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | COX-2 inhibitor NS-398 suppresses doxorubicin-induced p53 accumulation through inhibition of ROS-mediated Jnk activation. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 2 | Pre-treatment with a reactive oxygen species (ROS) scavenger, N-acetylcysteine, attenuated DOX-induced Jnk activation and subsequent p53 accumulation. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 3 | Pre-treatment with a reactive oxygen species (ROS) scavenger, N-acetylcysteine, attenuated DOX-induced Jnk activation and subsequent p53 accumulation. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 4 | These results suggest that COX-2 activates Jnk through modulation of ROS levels, leading to accumulation of p53. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |