Title : Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies.

Pub. Date : 2016 Jan 26

PMID : 26755576






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Further mechanistic analyses reveal that GOF mutant Shp2 hyperactivates the Polo-like kinase 1 (Plk1) kinase by enhancing c-Src kinase-mediated tyrosine phosphorylation of Plk1. Tyrosine C-terminal Src kinase Homo sapiens