Pub. Date : 2017 May
PMID : 26752591
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To characterize the ability of ALK to control ethanol consumption, we treated mice with the ALK inhibitors TAE684 or alectinib before testing them for binge-like drinking using the drinking in the dark protocol. | Ethanol | anaplastic lymphoma kinase | Mus musculus |
| 2 | Mice treated with ALK inhibitors drank less ethanol than controls. | Ethanol | anaplastic lymphoma kinase | Mus musculus |
| 3 | In addition, TAE684 treatment abolished ethanol conditioned place preference, indicating that ALK regulates the rewarding properties of ethanol. | Ethanol | anaplastic lymphoma kinase | Mus musculus |
| 4 | In addition, TAE684 treatment abolished ethanol conditioned place preference, indicating that ALK regulates the rewarding properties of ethanol. | Ethanol | anaplastic lymphoma kinase | Mus musculus |
| 5 | Because the ventral tegmental area (VTA) is a key brain region involved in the rewarding effects of ethanol, we determined if Alk expression in the VTA is important for binge-like ethanol consumption. | Ethanol | anaplastic lymphoma kinase | Mus musculus |
| 6 | Mice expressing a short hairpin ribonucleic acid targeting Alk in the VTA drank less ethanol compared with controls. | Ethanol | anaplastic lymphoma kinase | Mus musculus |