Title : Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase.

Pub. Date : 2016 Feb 10

PMID : 26731630






2 Functional Relationships(s)
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1 These features launched AChE as a reaction vessel for in situ click-chemistry synthesis of high-affinity TZ2PA6 and TZ2PA5 inhibitors, forming a syn-triazole upon cycloaddition within the gorge from alkyne and azide reactants bound at the two sites, respectively. Azides acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Despite precursor binding to crystalline AChE, coupling of rapid electric field fluctuations in the gorge with proper alignments of the azide and alkyne reactants to form the triazole remains a likely limiting step. Azides acetylcholinesterase (Cartwright blood group) Homo sapiens