Title : Improved transcription and translation with L-leucine stimulation of mTORC1 in Roberts syndrome.

Pub. Date : 2016 Jan 5

PMID : 26729373






2 Functional Relationships(s)
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1 L-leucine treatment partially rescued translational efficiency of ribosomal subunits, translation initiation factors, snoRNA production, and mitochondrial function in RBS cells, consistent with these processes being mTORC1 controlled. Leucine CREB regulated transcription coactivator 1 Mus musculus
2 This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS cells and supports that normal gene expression and translation requires ESCO2 function. Leucine CREB regulated transcription coactivator 1 Mus musculus