Pub. Date : 2016 Apr
PMID : 26724201
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Understanding the accumulation of P-glycoprotein substrates within cells: The effect of cholesterol on membrane partitioning. | Cholesterol | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | The apparent activity of the multidrug transporter P-glycoprotein (P-gp) is enhanced by the presence of cholesterol. | Cholesterol | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | The apparent activity of the multidrug transporter P-glycoprotein (P-gp) is enhanced by the presence of cholesterol. | Cholesterol | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Whether this is due to the direct effect of cholesterol on the activity of P-gp, its effect on the local concentration of substrate in the membrane, or its effect on the rate of entry of the drug into the cell, is unknown. | Cholesterol | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | In this study, molecular dynamics simulation techniques coupled with potential of mean force calculations have been used to investigate the role of cholesterol in the movement of four P-gp substrates across a POPC bilayer in the presence or absence of 10% cholesterol. | Cholesterol | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | These findings suggest that P-gp substrates may preferentially accumulate in cholesterol-rich regions of the membrane, which may explain its enhanced transport activity. | Cholesterol | ATP binding cassette subfamily B member 1 | Homo sapiens |