Pub. Date : 2016 Feb
PMID : 26721344
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | beta-Elemene induces apoptosis of human rheumatoid arthritis fibroblast-like synoviocytes via reactive oxygen species-dependent activation of p38 mitogen-activated protein kinase. | beta-elemene | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | beta-Elemene treatment caused an enhancement of p38 MAPK phosphorylation and ROS production. | beta-elemene | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | The pro-apoptotic activity of beta-elemene was significantly reversed by pretreatment with the p38 inhibitor SB203580 or ROS inhibitor N-acetyl-l-cysteine. | beta-elemene | mitogen-activated protein kinase 14 | Homo sapiens |
| 4 | CONCLUSIONS: Taken together, beta-elemene is effective in inducing mitochondrial apoptosis of RA-FLS, which is mediated through induction of ROS formation and p38 MAPK activation. | beta-elemene | mitogen-activated protein kinase 14 | Homo sapiens |