Title : Arylacetamide Deacetylase is Responsible for Activation of Prasugrel in Human and Dog.

Pub. Date : 2016 Mar

PMID : 26718653






1 Functional Relationships(s)
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1 Recombinant human AADAC was shown to catalyze prasugrel hydrolysis with a CLint value of 50.0 +- 1.2 ml/min/mg protein with a similar Km value to human intestinal and liver microsomes, whereas the CLint values of human CES1 and CES2 were 4.6 +- 0.1 and 6.6 +- 0.3 ml/min/mg protein, respectively. Prasugrel Hydrochloride carboxylesterase 1 Homo sapiens