Title : Combination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells.

Pub. Date : 2016 Apr

PMID : 26704388






3 Functional Relationships(s)
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Protein Name
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1 A role for p53 appears important as GCS-100 induces p53 expression and shRNA knockdown of p53 protected OCI-AML3 cells from the cytotoxic effects of the GCS-100/ABT-737 treatment combination. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid tumor protein p53 Homo sapiens
2 A role for p53 appears important as GCS-100 induces p53 expression and shRNA knockdown of p53 protected OCI-AML3 cells from the cytotoxic effects of the GCS-100/ABT-737 treatment combination. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid tumor protein p53 Homo sapiens
3 A role for p53 appears important as GCS-100 induces p53 expression and shRNA knockdown of p53 protected OCI-AML3 cells from the cytotoxic effects of the GCS-100/ABT-737 treatment combination. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid tumor protein p53 Homo sapiens