Pub. Date : 2016 Feb 1
PMID : 26702643
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Nonmetabolized beta-Blocker Nadolol Is a Substrate of OCT1, OCT2, MATE1, MATE2-K, and P-Glycoprotein, but Not of OATP1B1 and OATP1B3. | Nadolol | POU class 2 homeobox 2 | Homo sapiens |
| 2 | In contrast, a significantly higher nadolol accumulation (at 1 and 10 muM) was found in OCT1, OCT2, MATE1, and MATE2-K cells compared to control cells (P < 0.01). | Nadolol | POU class 2 homeobox 2 | Homo sapiens |
| 3 | Km values for OCT2-, MATE1-, and MATE2-K-mediated nadolol uptake were 122, 531, and 372 muM, respectively. | Nadolol | POU class 2 homeobox 2 | Homo sapiens |
| 4 | In summary, nadolol is a substrate of the cation transporters OCT1, OCT2, MATE1, MATE2-K, and of P-gp. | Nadolol | POU class 2 homeobox 2 | Homo sapiens |