Title : Cu,Zn-Superoxide Dismutase-Mediated Redox Regulation of Jumonji Domain Containing 3 Modulates Macrophage Polarization and Pulmonary Fibrosis.

Pub. Date : 2016 Jul

PMID : 26699812






1 Functional Relationships(s)
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1 Because Cu,Zn-superoxide dismutase-induced H2O2 can polarize macrophages to a profibrotic M2 phenotype, we hypothesized that modulation of the redox state of the cell is involved in the epigenetic modulation of the macrophage phenotype. Hydrogen Peroxide superoxide dismutase 1 Homo sapiens