Pub. Date : 2016 Jan 27
PMID : 26698536
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pyridazinone derivatives displaying highly potent and selective inhibitory activities against c-Met tyrosine kinase. | 2-phenyl-3(2H)-pyridazinone | met proto-oncogene | Mus musculus |
| 2 | A structure-activity relationship (SAR) study of these substances led to identification of pyridazinone 19 as a highly selective and potent c-Met tyrosine inhibitor, which displays favorable pharmacokinetic properties in mice and significant antitumor activity against a c-Met driven EBC-1 tumor xenograft. | 2-phenyl-3(2H)-pyridazinone | met proto-oncogene | Mus musculus |
| 3 | A structure-activity relationship (SAR) study of these substances led to identification of pyridazinone 19 as a highly selective and potent c-Met tyrosine inhibitor, which displays favorable pharmacokinetic properties in mice and significant antitumor activity against a c-Met driven EBC-1 tumor xenograft. | 2-phenyl-3(2H)-pyridazinone | met proto-oncogene | Mus musculus |