Pub. Date : 2016 Jan
PMID : 26696550
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TP53 Codon 72 Polymorphism Predicts Efficacy of Paclitaxel Plus Capecitabine Chemotherapy in Advanced Gastric Cancer Patients. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 2 | BACKGROUND AND AIMS: The present study analyzed the relationship between TP53 codon 72 polymorphisms and the clinical outcome of advanced gastric cancer patients receiving capecitabine plus paclitaxel chemotherapy. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 3 | RESULTS: The Pro/Pro genotypes of TP53 codon 72 were significantly correlated with a lower response rate to capecitabine plus paclitaxel chemotherapy in patients with gastric cancer when compared to the Arg/Arg genotype (30.6 vs. 63.2%, p value 0.000). | Paclitaxel | tumor protein p53 | Homo sapiens |
| 4 | CONCLUSIONS: TP53 codon 72 polymorphisms was effective in predicting the response to chemotherapy and correlate with PFS and OS in patients with advanced gastric cancer treated with paclitaxel and capecitabine chemotherapy. | Paclitaxel | tumor protein p53 | Homo sapiens |