Pub. Date : 2016 Jan 15
PMID : 26694802
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RA significantly decreased the levels of interleukin (IL)-13 and phosphorylated the signal transducer and activation of transcription 6 in the TSLP-stimulated HMC-1 cells. | rosmarinic acid | thymic stromal lymphopoietin | Homo sapiens |
| 2 | Inhibition of MDM2 expression by rosmarinic acid in TSLP-stimulated mast cell. | rosmarinic acid | thymic stromal lymphopoietin | Homo sapiens |
| 3 | Thus, the aim of this study was to determine the regulatory effect of RA in TSLP-stimulated human mast cell line, HMC-1 cells, and short ragweed pollen-induced allergic conjunctivitis mouse model. | rosmarinic acid | thymic stromal lymphopoietin | Homo sapiens |
| 4 | RA significantly reduced the production of tumor necrosis factor-alpha, IL-1beta, and IL-6 on the TSLP-stimulated HMC-1 cells. | rosmarinic acid | thymic stromal lymphopoietin | Homo sapiens |
| 5 | In addition, RA significantly reduced the levels of IgE, IL-4, and TSLP in the short ragweed pollen-induced allergic conjunctivitis mouse model. | rosmarinic acid | thymic stromal lymphopoietin | Homo sapiens |
| 6 | In conclusion, the results of the study suggest that RA has a significant anti-inflammatory effect on TSLP-induced inflammatory reactions. | rosmarinic acid | thymic stromal lymphopoietin | Homo sapiens |
| 7 | These effects of RA are likely to be mediated through inhibiting the MDM2 increased by TSLP. | rosmarinic acid | thymic stromal lymphopoietin | Homo sapiens |