Title : The Lipoxygenases: Their Regulation and Implication in Alzheimer's Disease.

Pub. Date : 2016 Feb

PMID : 26677076






1 Functional Relationships(s)
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1 Polyunsaturated fatty acids (PUFA) metabolism impaired by cyclooxygenases (COX-1, COX-2), which are responsible for formation of several eicosanoids, and by lipoxygenases (LOXs) that catalyze the addition of oxygen to linolenic, arachidonic (AA), and docosahexaenoic acids (DHA) and other PUFA leading to formation of bioactive lipids, significantly affects the course of neurodegenerative diseases. Eicosanoids mitochondrially encoded cytochrome c oxidase II Homo sapiens