Title : The pan-class I phosphatidyl-inositol-3 kinase inhibitor NVP-BKM120 demonstrates anti-leukemic activity in acute myeloid leukemia.

Pub. Date : 2015 Dec 17

PMID : 26674543






1 Functional Relationships(s)
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1 Our results demonstrate that BKM120 abrogates the activity of the PI3K/Akt/mTOR signaling, promoting cell growth arrest and significant apoptosis in a dose- and time-dependent manner in AML cells but not in the normal counterpart. NVP-BKM120 thymoma viral proto-oncogene 1 Mus musculus