Pub. Date : 2015 Dec 17
PMID : 26673665
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BKM120 activity induced the blockage of PI3K/AKT signaling and NF-kappaB expression, which in turn led to activate caspase-3/7 and caspase-9 and changed the expression of several apoptosis-related gene expression. | NVP-BKM120 | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Our findings indicate that BKM120 partially overcomes the MDR phenotype in chemoresistant breast cancer through cell apoptosis induction and CSC abolishing, which appears to be mediated by the inhibition of the PI3K/AKT/NF-kappaB axis. | NVP-BKM120 | AKT serine/threonine kinase 1 | Homo sapiens |