Pub. Date : 2016 Jan 15
PMID : 26663722
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Targeting Ornithine Decarboxylase by alpha-Difluoromethylornithine Inhibits Tumor Growth by Impairing Myeloid-Derived Suppressor Cells. | Eflornithine | ornithine decarboxylase, structural 1 | Mus musculus |
| 2 | However, little is known about the effect of ornithine decarboxylase (ODC) inhibition by DFMO on antitumor immune responses. | Eflornithine | ornithine decarboxylase, structural 1 | Mus musculus |
| 3 | However, little is known about the effect of ornithine decarboxylase (ODC) inhibition by DFMO on antitumor immune responses. | Eflornithine | ornithine decarboxylase, structural 1 | Mus musculus |
| 4 | We showed in this study that pharmacologic blockade of ODC by DFMO inhibited tumor growth in intact immunocompetent mice, but abrogated in the immunodeficient Rag1(-/-) mice, suggesting that antitumor effect of DFMO is dependent on the induction of adaptive antitumor T cell immune responses. | Eflornithine | ornithine decarboxylase, structural 1 | Mus musculus |
| 5 | We showed in this study that pharmacologic blockade of ODC by DFMO inhibited tumor growth in intact immunocompetent mice, but abrogated in the immunodeficient Rag1(-/-) mice, suggesting that antitumor effect of DFMO is dependent on the induction of adaptive antitumor T cell immune responses. | Eflornithine | ornithine decarboxylase, structural 1 | Mus musculus |
| 6 | Our findings establish a new role of ODC inhibition by DFMO as a viable and effective immunological adjunct in effective cancer treatment, thereby adding to the growing list of chemoimmunotherapeutic applications of these agents. | Eflornithine | ornithine decarboxylase, structural 1 | Mus musculus |