Title : Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.

Pub. Date : 2016 Jan 29

PMID : 26663083






1 Functional Relationships(s)
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1 Blocking autophagy by treating cells with 3-methyladenine or overexpressing dominant-negative ATG5 abolished the deficiency of the p38alpha MAPK-induced BACE1 protein reduction in cultured cells. 3-methyladenine mitogen-activated protein kinase 14 Mus musculus