Title : Inhibitory Effect of Memantine on Streptozotocin-Induced Insulin Receptor Dysfunction, Neuroinflammation, Amyloidogenesis, and Neurotrophic Factor Decline in Astrocytes.

Pub. Date : 2016 Dec

PMID : 26660109






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Treatment with memantine (1-10 muM) improved STZ-induced neurotrophic factor decline (BDNF, GDNF) along with IR dysfunction as evidenced by a significant increase in IR protein expression, phosphorylation of IRS-1, Akt, and GSK-3 alpha/beta in astrocytes. Memantine AKT serine/threonine kinase 1 Homo sapiens