Title : Indoxyl sulfate enhances IL-1β-induced E-selectin expression in endothelial cells in acute kidney injury by the ROS/MAPKs/NFκB/AP-1 pathway.

Pub. Date : 2016 Nov

PMID : 26659566






1 Functional Relationships(s)
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1 IS pretreatment of HUVECs significantly increased IL-1beta-induced E-selectin expression, monocyte adhesion, and the phosphorylation of mitogen-activated protein kinases (ERK, p38, and JNK) and transcription factors (NF-kappaB and AP-1), and phosphorylation was decreased by pretreatment with inhibitors of ERK1/2 (PD98059), p38 MAPK (SB202190), and JNK (SP600125). pyrazolanthrone interleukin 1 beta Homo sapiens