Pub. Date : 2016 Feb
PMID : 26647854
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of the present study was to examine the role of the CPT I-dependent peroxisome proliferator-activated receptor (PPAR)gamma signaling pathway in the ameliorative effect of L-carnitine on the liver inflammatory response. | Carnitine | carnitine palmitoyltransferase 1b, muscle | Mus musculus |
| 2 | These changes induced by L-carnitine were reversed by treatment with etomoxir, an inhibitor of CPT I. | Carnitine | carnitine palmitoyltransferase 1b, muscle | Mus musculus |
| 3 | Taken together, these results demonstrated that L-carnitine ameliorated liver inflammation and serum pro-inflammatory markers in cancer cachexia through regulating CPT I-dependent PPARgamma signaling, including the downstream molecules of NF-kappaB p65 and Cox-2. | Carnitine | carnitine palmitoyltransferase 1b, muscle | Mus musculus |