Pub. Date : 2016 Feb
PMID : 26647854
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | L-carnitine ameliorates the liver inflammatory response by regulating carnitine palmitoyltransferase I-dependent PPARgamma signaling. | Carnitine | peroxisome proliferator activated receptor gamma | Mus musculus |
| 2 | The results showed that oral administration of L-carnitine in these mice improved hepatocyte necrosis, liver cell cord derangement and hydropic or fatty degeneration of the liver cells in the liver tissues, decreased serum levels of malondialdehyde, increased serum levels of superoxide dismutase and glutathione peroxidase, and elevated the expression levels of PPARalpha and PPARgamma at the mRNA and protein levels. | Carnitine | peroxisome proliferator activated receptor gamma | Mus musculus |
| 3 | The inhibitory effect of L-carnitine on the increased expression level of nuclear factor (NF)-kappaB p65 in the peripheral blood mononuclear cells was markedly weakened by GW9662, a selective inhibitor of PPAR-gamma. | Carnitine | peroxisome proliferator activated receptor gamma | Mus musculus |
| 4 | Taken together, these results demonstrated that L-carnitine ameliorated liver inflammation and serum pro-inflammatory markers in cancer cachexia through regulating CPT I-dependent PPARgamma signaling, including the downstream molecules of NF-kappaB p65 and Cox-2. | Carnitine | peroxisome proliferator activated receptor gamma | Mus musculus |