Title : CREB pathway links PGE2 signaling with macrophage polarization.

Pub. Date : 2015 Dec 22

PMID : 26644581






1 Functional Relationships(s)
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1 Targeted disruption of CREB or the cAMP-regulated transcriptional coactivators 2 and 3 (CRTC2/3) in macrophages down-regulated M2 marker gene expression and promoted insulin resistance in the context of high-fat diet feeding. Cyclic AMP insulin Homo sapiens