Title : Dehydroepiandrosterone ameliorates H2O2-induced Leydig cells oxidation damage and apoptosis through inhibition of ROS production and activation of PI3K/Akt pathways.

Pub. Date : 2016 Jan

PMID : 26643608






3 Functional Relationships(s)
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1 Dehydroepiandrosterone ameliorates H2O2-induced Leydig cells oxidation damage and apoptosis through inhibition of ROS production and activation of PI3K/Akt pathways. Hydrogen Peroxide AKT serine/threonine kinase 1 Homo sapiens
2 DHEA also reversed the decrease in PI3K and p-Akt protein levels induced by H2O2. Hydrogen Peroxide AKT serine/threonine kinase 1 Homo sapiens
3 These data showed that DHEA could ameliorate H2O2-induced oxidative damage by increasing anti-oxidative enzyme activities, which resulted in reduced ROS content, and decreased apoptosis, mainly by preventing the loss of DeltaPsim and inhibiting caspase-3 protein levels via activation of PI3K/Akt signaling pathways. Hydrogen Peroxide AKT serine/threonine kinase 1 Homo sapiens