Title : Erythropoietin alleviates hepatic insulin resistance via PPARγ-dependent AKT activation.

Pub. Date : 2015 Dec 8

PMID : 26643367






2 Functional Relationships(s)
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1 Here, we report that EPO administration promoted phosphatidylinositol 3-kinase (PI3K)/AKT pathway activation in palmitic acid (PA)-treated HepG2 cells and in the liver of high-fat diet (HFD)-fed mice, whereas adenovirus-mediated silencing of the erythropoietin receptor (EPOR) blocked EPO-induced AKT signalling in HepG2 cells. Palmitic Acid thymoma viral proto-oncogene 1 Mus musculus
2 Here, we report that EPO administration promoted phosphatidylinositol 3-kinase (PI3K)/AKT pathway activation in palmitic acid (PA)-treated HepG2 cells and in the liver of high-fat diet (HFD)-fed mice, whereas adenovirus-mediated silencing of the erythropoietin receptor (EPOR) blocked EPO-induced AKT signalling in HepG2 cells. Palmitic Acid thymoma viral proto-oncogene 1 Mus musculus