Title : Histone deacetylase inhibitor valproic acid (VPA) promotes the epithelial mesenchymal transition of colorectal cancer cells via up regulation of Snail.

Pub. Date : 2015

PMID : 26632346






2 Functional Relationships(s)
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1 VPA also increases the phosphorylation of Akt/GSK-3beta. Valproic Acid glycogen synthase kinase 3 beta Homo sapiens
2 The inhibitor of PI3K/Akt, LY2994002, significantly attenuates VPA induced phosphorylation of Akt and GSK-3beta and up regulation of Snail and Vim. Valproic Acid glycogen synthase kinase 3 beta Homo sapiens