Title : Vitamin C inhibit the proliferation, migration and epithelial-mesenchymal-transition of lens epithelial cells by destabilizing HIF-1α.

Pub. Date : 2015

PMID : 26628999






2 Functional Relationships(s)
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1 We also found that vitamin C could increase the proline hydroxylation of HIF-1alpha and reduce the activity of HIF-1alpha. Proline hypoxia inducible factor 1 subunit alpha Homo sapiens
2 Overexpression of wild-type HIF-1alpha or proline-mutant HIF-1alpha was found to increase the proliferation and migration of human lens epithelial cells. Proline hypoxia inducible factor 1 subunit alpha Homo sapiens