Title : Guggulsterone inhibits human cholangiocarcinoma Sk-ChA-1 and Mz-ChA-1 cell growth by inducing caspase-dependent apoptosis and downregulation of survivin and Bcl-2 expression.

Pub. Date : 2015 Sep

PMID : 26622683






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In addition, guggulsterone-induced apoptosis of cholangiocarcinoma cells was demonstrated to be partially inhibited by the caspase inhibitors z-VAD-fmk, z-LEHD-fmk and z-IETD-fmk, accompanied by the activation of caspases-3, -8 and -9, accumulation of cleaved PARP and decreased expression of survivin and Bcl-2. pregna-4,17-diene-3,16-dione caspase 3 Homo sapiens