Title : Influence of Nitroxide Spin Labels on RNA Structure: A Molecular Dynamics Simulation Study.

Pub. Date : 2008 Oct 14

PMID : 26620180






3 Functional Relationships(s)
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Protein Name
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1 The technique requires attachment of nitroxide spin labels to the nucleotides, which may possibly perturb its conformation. Hydroxylamine spindlin 1 Homo sapiens
2 To study to what extent nitroxide spin labels may affect RNA structure, all-atom molecular dynamics simulations in explicit solvent are performed for six double-labeled RNA duplexes. Hydroxylamine spindlin 1 Homo sapiens
3 A new parametrization of the force field for the nitroxide spin label is developed, which leads to intramolecular distances that are in good agreement with experimental results. Hydroxylamine spindlin 1 Homo sapiens