Title : Targeted mutations in Val101 and Arg27 interferon beta protein increase its transcriptional and translational activities.

Pub. Date : 2016 Feb

PMID : 26615566






2 Functional Relationships(s)
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1 It could be concluded that the substitution of Phe in the codon 101 position, which may increase the binding activity of IFNbeta with its receptors and introduction of an additional N glycosylation site (Asn-X-Thr) in the position 27 of IFNbeta protein may cause such an effect. Phenylalanine interferon beta 1 Homo sapiens
2 It could be concluded that the substitution of Phe in the codon 101 position, which may increase the binding activity of IFNbeta with its receptors and introduction of an additional N glycosylation site (Asn-X-Thr) in the position 27 of IFNbeta protein may cause such an effect. Phenylalanine interferon beta 1 Homo sapiens