Title : Toward the understanding of the molecular basis for the inhibition of COX-1 and COX-2 by phenolic compounds present in Uruguayan propolis and grape pomace.

Pub. Date : 2016 Dec

PMID : 26610257






1 Functional Relationships(s)
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1 Based on phenols previously identified, and taking as reference the crystallographic structures of COX-1 and COX-2 in complex with the commercial drug Celecoxib, a molecular docking procedure was devised to adjust 123 phenolic molecular models at the enzyme-binding sites. Celecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens