Pub. Date : 2016 Jan 1
PMID : 26607110
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | miR-4458 suppresses glycolysis and lactate production by directly targeting hexokinase2 in colon cancer cells. | Lactic Acid | hexokinase 2 | Homo sapiens |
| 2 | Using bioinformatic databases, we predicted that hexokinase2 (HK2), a rate-limiting enzyme in the glycolytic pathway, was a target of miR-4458, so the effects of miR-4458 on glycolysis and lactate production was assessed in colon cancer cells. | Lactic Acid | hexokinase 2 | Homo sapiens |
| 3 | Using bioinformatic databases, we predicted that hexokinase2 (HK2), a rate-limiting enzyme in the glycolytic pathway, was a target of miR-4458, so the effects of miR-4458 on glycolysis and lactate production was assessed in colon cancer cells. | Lactic Acid | hexokinase 2 | Homo sapiens |
| 4 | Moreover, knockdown of HK2 by specific RNAi also suppressed proliferation, glycolysis, and lactate production under both normoxic and hypoxic conditions. | Lactic Acid | hexokinase 2 | Homo sapiens |
| 5 | In conclusion, our findings suggested that miR-4458 inhibited the progression of colon cancer cells by inhibition of glycolysis and lactate production via directly targeting HK2 mRNA. | Lactic Acid | hexokinase 2 | Homo sapiens |