Title : Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis.

Pub. Date : 2015 Nov 21

PMID : 26604643






1 Functional Relationships(s)
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1 These results suggest that Huh7.5 cells either infected with HCV or ectopically expressing HCV NS5A alone have the potential to induce insulin resistance by the phosphorylation of IRS-1 at serine residue (Ser(307)) followed by decreased phosphorylation of Akt Thr(308), Fox01 Ser(256) and GSK3beta Ser(9), the downstream players of the insulin signaling pathway. Threonine insulin Homo sapiens