Title : Meloxicam increases intracellular accumulation of doxorubicin via downregulation of multidrug resistance-associated protein 1 (MRP1) in A549 cells.

Pub. Date : 2015 Nov 19

PMID : 26600514






2 Functional Relationships(s)
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1 In the present study, the ability of meloxicam, a COX-2-specific inhibitor to enhance doxorubicin-mediated inhibition was investigated in human A549 lung cancer in vivo and in vitro. Meloxicam mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 The results reported in the present study demonstrate for the first time that the specific COX-2 inhibitor meloxicam can increase the intracellular accumulation of doxorubicin and enhance doxorubicin-induced cytotoxicity in A549 cancer cells by reducing the expression of MRP1 and MRP4. Meloxicam mitochondrially encoded cytochrome c oxidase II Homo sapiens