Pub. Date : 2016 May
PMID : 26596838
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Aspirin acetylates wild type and mutant p53 in colon cancer cells: identification of aspirin acetylated sites on recombinant p53. | Aspirin | tumor protein p53 | Homo sapiens |
| 2 | Aspirin acetylates wild type and mutant p53 in colon cancer cells: identification of aspirin acetylated sites on recombinant p53. | Aspirin | tumor protein p53 | Homo sapiens |
| 3 | Aspirin acetylates wild type and mutant p53 in colon cancer cells: identification of aspirin acetylated sites on recombinant p53. | Aspirin | tumor protein p53 | Homo sapiens |
| 4 | We previously demonstrated that aspirin acetylated the tumor suppressor protein p53 at lysine 382 in MDA-MB-231 human breast cancer cells. | Aspirin | tumor protein p53 | Homo sapiens |
| 5 | We demonstrate that aspirin induced acetylation of p53 in both cell lines in a concentration-dependent manner. | Aspirin | tumor protein p53 | Homo sapiens |
| 6 | Aspirin-acetylated p53 was localized to the nucleus. | Aspirin | tumor protein p53 | Homo sapiens |
| 7 | Aspirin also acetylated recombinant p53 (rp53) in vitro suggesting that it occurs through a non-enzymatic chemical reaction. | Aspirin | tumor protein p53 | Homo sapiens |
| 8 | Our results suggest that aspirin"s anti-cancer effect may involve acetylation and activation of wild type and mutant p53 and induction of target gene expression. | Aspirin | tumor protein p53 | Homo sapiens |
| 9 | This is the first report attempting to characterize p53 acetylation sites targeted by aspirin. | Aspirin | tumor protein p53 | Homo sapiens |