Title : Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37.

Pub. Date : 2016 Feb

PMID : 26585423






5 Functional Relationships(s)
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1 Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37. Vitamin D cathelicidin antimicrobial peptide Homo sapiens
2 RV and LL-37 levels were measured in bronchoalveolar lavage (BAL) of CF children infected with RV.Vitamin D reduced RV16 load in a dose-dependent manner in CF cells (10(-7 )M, p<0.01). Vitamin D cathelicidin antimicrobial peptide Homo sapiens
3 Vitamin D increased the expression of the antimicrobial peptide LL-37 up to 17.4-fold (p<0.05). Vitamin D cathelicidin antimicrobial peptide Homo sapiens
4 An inverse correlation between viral load and LL-37 levels in CF BAL (r=-0.48, p<0.05) was observed.RV replication in primary CF bronchial cells was reduced by vitamin D through the induction of LL-37. Vitamin D cathelicidin antimicrobial peptide Homo sapiens
5 An inverse correlation between viral load and LL-37 levels in CF BAL (r=-0.48, p<0.05) was observed.RV replication in primary CF bronchial cells was reduced by vitamin D through the induction of LL-37. Vitamin D cathelicidin antimicrobial peptide Homo sapiens