Title : Lico A Enhances Nrf2-Mediated Defense Mechanisms against t-BHP-Induced Oxidative Stress and Cell Death via Akt and ERK Activation in RAW 264.7 Cells.

Pub. Date : 2015

PMID : 26576227






2 Functional Relationships(s)
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1 Furthermore, Lico A treatment markedly attenuated t-BHP-induced oxidative damage, which was reduced by treatment with PI3K/Akt, ERK, and HO-1 inhibitors. tert-Butylhydroperoxide thymoma viral proto-oncogene 1 Mus musculus
2 Therefore, Lico A might have a protective role against t-BHP-induced cytotoxicity by modulating HO-1 and by scavenging ROS via the activation of the PI3K/Akt and ERK/Nrf2 signaling pathways. tert-Butylhydroperoxide thymoma viral proto-oncogene 1 Mus musculus