Title : Theophylline Represses IL-8 Secretion from Airway Smooth Muscle Cells Independently of Phosphodiesterase Inhibition. Novel Role as a Protein Phosphatase 2A Activator.

Pub. Date : 2016 Jun

PMID : 26574643






2 Functional Relationships(s)
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1 However, theophylline (at 10 muM) was antiinflammatory and repressed secretion of the neutrophil chemoattractant cytokine IL-8, which is produced in response to TNF-alpha. Theophylline tumor necrosis factor Homo sapiens
2 We investigated the impact of theophylline on protein phosphatase (PP) 2A, a master controller of multiple inflammatory signaling pathways, and show that theophylline increases TNF-alpha-induced PP2A activity in ASM cells. Theophylline tumor necrosis factor Homo sapiens