Pub. Date : 2016 Jan
PMID : 26574555
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A selective beta2AR antagonist mirrored propranolol"s effects on HemSCs in a dose-dependent fashion, and a selective beta1AR antagonist had no effect, supporting a role for beta2AR signaling in IH pathobiology. | Propranolol | adrenoceptor beta 2 | Homo sapiens |
| 2 | We have thus demonstrated that propranolol acts on HemSCs in IH to suppress proliferation and promote apoptosis in a dose-dependent fashion via beta2AR perturbation, resulting in reduced cAMP and MAPK activation. | Propranolol | adrenoceptor beta 2 | Homo sapiens |
| 3 | Furthermore, propranolol acts via perturbation of beta2AR, and not beta1AR, although both receptors are expressed in HemSCs. | Propranolol | adrenoceptor beta 2 | Homo sapiens |