Title : Variability in penetrance of multiple endocrine neoplasia 2A with amino acid substitutions in RET codon 634.

Pub. Date : 2016 Feb

PMID : 26572832






5 Functional Relationships(s)
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1 OBJECTIVE: Controversy surrounds the importance of the different amino acids substituting for cysteine in REarranged during Transfection (RET) codon 634 for multiple endocrine neoplasia 2A (MEN 2A). Cysteine ret proto-oncogene Homo sapiens
2 OBJECTIVE: Controversy surrounds the importance of the different amino acids substituting for cysteine in REarranged during Transfection (RET) codon 634 for multiple endocrine neoplasia 2A (MEN 2A). Cysteine ret proto-oncogene Homo sapiens
3 OBJECTIVE: Controversy surrounds the importance of the different amino acids substituting for cysteine in REarranged during Transfection (RET) codon 634 for multiple endocrine neoplasia 2A (MEN 2A). Cysteine ret proto-oncogene Homo sapiens
4 OBJECTIVE: Controversy surrounds the importance of the different amino acids substituting for cysteine in REarranged during Transfection (RET) codon 634 for multiple endocrine neoplasia 2A (MEN 2A). Cysteine ret proto-oncogene Homo sapiens
5 CONCLUSIONS: In codon 634, arginine substitutions for cysteine may cause slightly higher penetrance rates of MEN 2A which, overall, are too small to treat carriers differently. Cysteine ret proto-oncogene Homo sapiens